League of Legends Patch: 9.12
Analysed 256,891 Platinum+ Vayne games this week

Vayne Highest Win Rune Page for Platinum+


Become a legend
Improved attacks and sustained damage


+9% Attack Speed
+6 Attack Damage or +10 Ability Power, Adaptive

Press the Attack

50.81% Win 83.76% Pick

Hitting an enemy champion 3 consecutive times makes them vunerable, dealing bonus damage...

Nullifying Orb

51.66% Win 1.24% Pick

Gain a magic damage shield when taken to low health by magic damage.


50.82% Win 8.85% Pick

Excess healing on you becomes a shield.


50.47% Win 5.01% Pick

Gain 2% extra MS. Gain extra AP or AD, adaptive based on your bonus MS.

Legend: Alacrity

50.75% Win 84.54% Pick

Takedowns on enemies grant permanent Attack Speed.

Coup de Grace

50.64% Win 90.29% Pick

Deal more damage to low health enemy champions.