League of Legends Patch: 10.3
Analysed 378,494 Platinum+ Vayne games this week

Vayne Highest Win Rune Page for Platinum+

PRECISION

Become a legend
Improved attacks and sustained damage

DOMINATION

+9% Attack Speed
+6 Attack Damage or +10 Ability Power, Adaptive

Press the Attack

51.04% Win 91.42% Pick

Hitting an enemy champion 3 consecutive times makes them vunerable, dealing bonus damage...

Taste of Blood

51.38% Win 23.67% Pick

Heal when you damage an enemy champion.

Triumph

50.90% Win 83.09% Pick

Takedowns restore 12% of your missing health and grant an additional 20 gold.

Ravenous Hunter

51.25% Win 27.34% Pick

Unique takedowns grant permanent healing from ability damage.

Legend: Alacrity

50.95% Win 81.29% Pick

Takedowns on enemies grant permanent Attack Speed.

Cut Down

51.17% Win 5.33% Pick

Deal more damage to champions with more max health than you.