League of Legends Patch: 9.4
Analysed 86,592 Platinum+ Lissandra games this week

Lissandra Highest Win Rune Page for Platinum+

RESOLVE

Live forever
Durability and crowd control

DOMINATION

+15-135 Health based on level
+5 Attack Damage or +9 Ability Power, Adaptive

Aftershock

51.01% Win 88.03% Pick

After immobilizing an enemy champion gain defenses and later deal a burst of adaptive damage...

Cheap Shot

52.64% Win 1.40% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Demolish

51.06% Win 70.85% Pick

Charge up a powerful attack against a tower while near it.

Ultimate Hunter

52.17% Win 1.44% Pick

Unique takedowns grant permanent cooldown reuction on your Ultimate.

Conditioning

51.55% Win 3.05% Pick

After 10 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 5%.

Overgrowth

51.08% Win 72.53% Pick

Gain additional permanent max health when minions or monsters die near you.