League of Legends Patch: 9.4
Analysed 77,194 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

52.07% Win 93.03% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

52.75% Win 85.05% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

52.32% Win 57.80% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

53.19% Win 4.36% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

52.15% Win 85.87% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

54.07% Win 44.11% Pick

Unique takedowns grant permanent healing from ability damage.