League of Legends Patch: 9.12
Analysed 69,768 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

50.10% Win 93.11% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

50.77% Win 86.50% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

50.48% Win 69.37% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

54.59% Win 4.68% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

50.22% Win 85.94% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

52.68% Win 48.63% Pick

Unique takedowns grant permanent healing from ability damage.