League of Legends Patch: 8.16
Analysed 29,295 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

SORCERY

Unleash Destruction
Empowered abilities and resource manipulation

DOMINATION

+12 Attack Damage or +20 Ability Power, Adaptive

Summon Aery

53.60% Win 55.13% Pick

Your attacks and abilities send Aery to a target, damaging enemies or shielding allies.

Eyeball Collection

53.40% Win 3.27% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Nullifying Orb

53.45% Win 10.19% Pick

Gain a magic damage shield when taken to low health by magic damage.

Ravenous Hunter

59.25% Win 1.37% Pick

Unique takedowns grant permanent healing from ability damage.

Absolute Focus

54.47% Win 20.96% Pick

While above 70% health, gain extra adaptive damage.

Scorch

53.54% Win 41.85% Pick

Your first ability hit every 20s burns champions.