League of Legends Patch: 9.16
Analysed 59,464 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

50.60% Win 95.03% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

51.09% Win 89.27% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

50.98% Win 75.31% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

54.50% Win 4.01% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

50.61% Win 88.22% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

53.10% Win 57.23% Pick

Unique takedowns grant permanent healing from ability damage.