League of Legends Patch: 9.23
Analysed 26,387 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

50.53% Win 92.81% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

51.46% Win 63.13% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

51.46% Win 73.50% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

57.37% Win 6.79% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

50.62% Win 85.25% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

53.77% Win 52.16% Pick

Unique takedowns grant permanent healing from ability damage.