League of Legends Patch: 10.3
Analysed 89,309 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

49.02% Win 96.55% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

50.13% Win 73.03% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

49.40% Win 81.00% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

52.66% Win 6.57% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

49.22% Win 90.29% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

51.17% Win 68.03% Pick

Unique takedowns grant permanent healing from ability damage.