League of Legends Patch: 9.20
Analysed 62,859 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

50.19% Win 94.97% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

50.56% Win 89.78% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Cheap Shot

50.61% Win 75.50% Pick

Deal bonus true damage to enemy champions with impaired movement or actions.

Last Stand

52.34% Win 7.20% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

50.32% Win 88.10% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

52.10% Win 59.82% Pick

Unique takedowns grant permanent healing from ability damage.