League of Legends Patch: 8.23
Analysed 71,759 Platinum+ Karthus games this week

Karthus Highest Win Rune Page for Platinum+

DOMINATION

Hunt and eliminate prey
Burst damage and target access

PRECISION

+8 Attack Damage or +14 Ability Power, Adaptive
+5.5% Attack Speed

Dark Harvest

52.52% Win 90.93% Pick

Champions, large minions, and large monsters drop soul essence on death. Touch souls to absorb...

Presence of Mind

53.44% Win 74.22% Pick

Takedowns restore 20% of your maximum mana and refund 10% of your ultimate's cooldown.

Taste of Blood

52.70% Win 59.44% Pick

Heal when you damage an enemy champion.

Last Stand

56.50% Win 6.97% Pick

Deal more damage to champions while you are low on health.

Eyeball Collection

52.58% Win 83.37% Pick

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, adaptive for each...

Ravenous Hunter

54.65% Win 11.53% Pick

Unique takedowns grant permanent healing from ability damage.