League of Legends Patch: 9.12
Analysed 33,144 Platinum+ Cassiopeia games this week

Cassiopeia Highest Win Rune Page for Platinum+

SORCERY

Unleash Destruction
Empowered abilities and resource manipulation

DOMINATION

+12 Attack Damage or +20 Ability Power, Adaptive

Phase Rush

50.45% Win 84.92% Pick

Hitting an enemy champion with 3 attacks or separate abilities grats a burst of MS.

Taste of Blood

50.94% Win 69.64% Pick

Heal when you damage an enemy champion.

Nullifying Orb

51.06% Win 5.26% Pick

Gain a magic damage shield when taken to low health by magic damage.

Ultimate Hunter

51.86% Win 1.05% Pick

Unique takedowns grant permanent cooldown reuction on your Ultimate.

Transcendence

50.84% Win 70.03% Pick

Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, adaptive.

Gathering Storm

50.49% Win 33.89% Pick

Gain increasing amounts of AD or AP, adaptive over the course of the game.